Gray matter lesions and cognitive impairment in multiple sclerosis

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[Gray matter lesions and cognitive impairment in multiple sclerosis].

Multiple sclerosis (MS) has long been considered to be the autoimmune disease that primarily affects oligodendrocyte and myelin in the white matter (WM) of the CNS. However, renewed interest in the gray matter (GM) pathology including cortical and deep GM of MS is emerging. Radiological and pathological assessments demonstrate that substantial cortical demyelination is prominent in all stages o...

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Gray matter networks and cognitive impairment in multiple sclerosis.

BACKGROUND Coordinated patterns of gray matter morphology can be represented as networks, and network disruptions may explain cognitive dysfunction related to multiple sclerosis (MS). OBJECTIVE To investigate whether single-subject gray matter network properties are related to impaired cognition in MS. METHODS We studied 148 MS patients (99 female) and 33 healthy controls (HC, 21 female). S...

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Gray Matters in Multiple Sclerosis: Cognitive Impairment and Structural MRI

Multiple sclerosis (MS) is an immune-mediated disease affecting central nervous system (CNS). Although MS is classically considered a white matter (WM) disease, the involvement of gray matter (GM) in the pathogenic process has been confirmed by pathology studies and MRI studies. Impairment of cognitive domains such as memory, mental processing speed, attention, and executive function can occur ...

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Iron and volume in the deep gray matter: association with cognitive impairment in multiple sclerosis.

BACKGROUND AND PURPOSE There is a well-established correlation between deep gray matter atrophy and cognitive dysfunction in MS. However, the cause of these signs of neurodegeneration is poorly understood. Iron accumulation in the deep gray matter is higher in patients with MS compared with age- and sex-matched healthy controls, and could contribute to disease progression. Our objective was to ...

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Contribution of Gray and White Matter Abnormalities to Cognitive Impairment in Multiple Sclerosis

Patients with multiple sclerosis (MS) commonly exhibit cognitive impairments (CI). However, the neural mechanisms underlying CI remain unclear. The current study applied diffusion tensor imaging (DTI) and voxel-based morphometric (VBM) magnetic resonance imaging (MRI) techniques to evaluate differences in white matter (WM) integrity and gray matter (GM) volume between MS patients with CI and MS...

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ژورنال

عنوان ژورنال: Rinsho Shinkeigaku

سال: 2014

ISSN: 0009-918X,1882-0654

DOI: 10.5692/clinicalneurol.54.1060